This is pretty cool! I especially like your take on Orpal, it really captures the feeling of crippling the opponent with -1/-1 runes (or Disease Counters as you’re calling them here). I think it might be better if the counters were put on the opponent instead, though, since it would feel weird and not disease-like if Orpal hitting one opponent in a 2v2 game let him take less damage from both opponents.
I do feel like the previous topic on this subject should be linked, though I think it’s good to have a new topic because of how long the previous one’s been inactive (many posts were broken by the Discourse updates changing formatting rules). There’s some different takes on the characters you have and some characters you don’t have yet, though not all of them are entirely serious…
Side-eyes Ardra’s Boulder